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KMID : 1144320230550020179
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감염과 화학요법
2023 Volume.55 No. 2 p.179 ~ p.184
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Antibiotic Combination Therapy for Severe Scrub Typhus: Is It Necessary?
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Chung Moon-Hyun
Lee Jin-Soo
Im Jae-Hyoung
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Abstract
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Scrub typhus can be adequately treated with doxycycline or azithromycin unless it is treated too late. Such cases present as severe scrub typhus, and their treatment remains a challenging problem. In this article, we briefly review the literature on the treatment of scrub typhus and the limitations of the combination of doxycycline and azithromycin. Several options are suggested for further study in the treatment of severe scrub typhus (such as encephalitis, myocarditis, and pneumonia), including dose escalation of doxycycline, the adjuvant use of steroids, the selective use of beta-lactam antibiotics, and the use of tigecycline.
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KEYWORD
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Azithromycin, Doxycycline, Drug synergism, Orientia tsutsugamushi, Scrub typhus
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